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Chalones of the liver

  • Experimental Biology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Injection of liver extract and blood serum of healthy intact mice and also of the blood serum from clinically healthy persons into CBA x C57BL hybrid mice sharply inhibits mitotic activity of hepatocytes in the liver regenerating after partial hepatectomy. Extracts of regenerating liver and blood serum of animals with a regenerating liver do not inhibit mitosis in hepatocytes. Blood serum from a patient with postnecrotic active cirrhosis of the liver not only did not inhibit mitoses in the hepatocytes but actually increased their number. It is suggested that the concentration of chalones is reduced in the cirrhotic liver.

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Authors and Affiliations

  1. Academy of Medical Sciences of the USSR, USSR

    A. S. Loginov (Corresponding Member)

Authors
  1. A. S. Loginov
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  2. M. D. Speranskii
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  3. L. I. Aruin
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  4. E. D. Matyushina
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  5. G. S. Magnitskii
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Additional information

Central Research Institute of Gastroenterology, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 82, No. 12, pp. 1482–1484, December, 1976.

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Loginov, A.S., Speranskii, M.D., Aruin, L.I. et al. Chalones of the liver. Bull Exp Biol Med 82, 1852–1854 (1976). https://doi.org/10.1007/BF00785717

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  • DOI: https://doi.org/10.1007/BF00785717

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