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Role of breakdown products of tissue macrophages in the regulation of granulocytopoiesis

  • Experimental Biology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

After intraperitoneal injection of breakdown products of rat peritoneal macrophages (BPM) into recipient rats leukocytosis was observed in the peripheral blood with an increase in mature forms of neutrophils and monocytes in the bone marrow and with an accompanying improvement in the oxygen supply of the bone marrow cells (as shown polarographically). Similar changes in the bone marrow were obtained after intraperitoneal injection of cytotoxic quartz dust particles. If mouse BPM were injected intraperitoneally into mice, the formation of granulocytic colonies in the spleen was sharply stimulated in syngenetic mice receiving a suspension of bone marrow or spleen cells taken from these donors by intravenous injection after lethal x-ray irradiation. The results are discussed in the light of the possible role of broken-down tissue macrophages in the formation of colony-stimulating factor and in the autoregulation of phagocytic reactions.

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Authors
  1. L. I. Privalova
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  2. A. V. Osipenko
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  3. V. N. Frash
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Privalova, L.I., Osipenko, A.V. & Frash, V.N. Role of breakdown products of tissue macrophages in the regulation of granulocytopoiesis. Bull Exp Biol Med 82, 1849–1852 (1976). https://doi.org/10.1007/BF00785716

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  • DOI: https://doi.org/10.1007/BF00785716

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