Abstract
Extract of Ehrlich's ascites tumor cells (chalone) and its cell-free fluid have a marked inhibitory action on proliferation of these tumor cells 4 h after injection. The effect is tissue specific, it is more marked in the extract, and it depends on the dose of the agent. Mitotic activity in the tumor 8 h after injection of the extract or cell-free fluid is higher than in the control, evidence of a short-term effect of the chalone on the G2 phase of the mitotic cycle and on synchronization of cell division.
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Romanov, Y.A., Rybakov, V.P., Antokhin, A.I. et al. Tissue-specific inhibition of cell proliferation in Ehrlich's ascites tumor. Bull Exp Biol Med 82, 1846–1848 (1976). https://doi.org/10.1007/BF00785715
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DOI: https://doi.org/10.1007/BF00785715