Skip to main content
SpringerLink
Log in

Correlation between tryptophan metabolism and the state of melaninogenesis

  • Biochemistry and Biophysics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

A study of the excretion of tryptophan metabolites and activity of liver tryptophan pyrrolase in black and white rabbits showed that the levels of kynurenin, kynurenic and xanthurenic acids, 3-hydroxykynurenin, anthranilic acid, and 5-hydroxyindoleacetic acid determined in the original urine before L-tryptophan loading differed in the two groups. No 3-hydroxyanthranilic acid was found in the original urine of the rabbits. After administration of L-tryptophan to albino rabbits, a sharp increase was observed in the excretion of all tryptophan metabolites investigated, but in black rabbits there was a sharper increase in the excretion of kynurenic and xanthurenic acids. The liver tryptophan pyrrolase reacts more intensively in white than in black rabbits to administration of L-tryptophan.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature Cited

  1. S. S. Burovina, “Activity of 5-hydroxytryptophan decarboxylase in tumors of man and animals”, Author's Abstract of Candidate's Dissertation, Moscow (1971).

  2. Kh. Kurbanov and T. T. Berezov, Vopr. Med. Khim., No. 4, 379 (1974).

    Google Scholar 

  3. Kh. Kurbanov and T. T. Berezov, Byull. Éksp. Biol. Med., No. 8, 44 (1975).

    Google Scholar 

  4. S. P. Lyakh and E. L. Ruban, Microbial Melanins [in Russian], Moscow (1972).

  5. V. K. Rudzit, Tryptophan [in Russian], Leningrad (1973).

  6. J. Borovansky and J. Duchan, Chem. Listy,65, 500 (1971).

    Google Scholar 

  7. R. R. Brown and J. M. Price, J. Biol. Chem.,219, 985 (1956).

    Google Scholar 

  8. D. Coppini, C. A. Benassi, and M. Montorsi, Clin. Chem.5, 391 (1959).

    Google Scholar 

  9. O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall, J. Biol. Chem.,193, 265 (1951).

    Google Scholar 

  10. E. H. Mandel and H. D. Appleton, Arch. Dermatol.,94, 358 (1966).

    Google Scholar 

  11. L. Musajo, in: Abstracts of the Seventh International Congress of Biochemistry, Vol. 3, Colloquia I–XIV, Tokyo (1967), p. 435.

  12. R. A. Nicolaus, Melanins, International Pubns. Service, New York (1968).

    Google Scholar 

  13. W. E. Knox, Methods Enzymol.,2, 242 (1955).

    Google Scholar 

  14. J. M. Price, R. R. Brown, et al., Adv. Metab. Disord.,2, 160 (1965).

    Google Scholar 

Download references

Authors
  1. Kh. Kurbanov
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kurbanov, K. Correlation between tryptophan metabolism and the state of melaninogenesis. Bull Exp Biol Med 82, 1799–1802 (1976). https://doi.org/10.1007/BF00785699

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00785699

Key Words

Search

Navigation