Effect of sodium succinate on some indices of carbohydrate metabolism of the ischemic myocardium
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The effect of sodium succinate on the concentrations of lactic and pyruvic acids and of glucose in blood draining from the ischemic zone was investigated in experiments on dogs in which the coronary artery was ligated. After intracoronary injection of the compound in doses of 2 and 10 mg/kg the lactic acid concentration was lowered in blood flowing from the ischemic zone: In a dose of 10 mg/kg sodium succinate reduced the assimilation of glucose by the ischemic area of myocardium a little. After intravenous injection of sodium succinate in a dose of 100 mg/kg the lactic acid concentration also fell significantly and the utilization of glucose by the ischemic myocardium was inhibited and its concentration in the arterial blood rose considerably. The reduction in the blood lactic acid concentration may have been due to activation of the Krebs' cycle and increased utilization of oxygen in the ischemic region of the myocardium.
Key Wordsmyocardial ischemia succinate carbohydrate metabolism
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