Bulletin of Experimental Biology and Medicine

, Volume 82, Issue 6, pp 1764–1767 | Cite as

Effect of injury to the zone of the medial forebrain bundle and preoptic region on activity of an epileptiform focus induced by penicillin (on the phenomenon of the hyperactive determinant dispatch station)

  • G. N. Kryzhanovskii
  • V. V. Ruseev
  • V. I. Ivanov
Pathological Physiology and General Pathology


Experiments on cats showed that injury to the medial forebrain bundle (MFB) and also partly to the preoptic region on the side of application of penicillin to the cerebral cortex (middle suprasylvian gyrus) causes depression of paroxysmal activity (spike potentials) in the penicillin focus, and also in a secondary “mirror” focus arising in the symmetrical zone of the opposite cortex. Injury to MFB on the side of the “mirror” focus causes depression of paroxysmal spike potentials only in that focus and does not affect activity in the primary epileptiform focus. The effects described are examined from the standpoint of views regarding the role of the determinant dispatch station (DDS) in the activity of the CNS: A primary epileptiform focus is a hyperactive DDS which induces the appearance of secondary foci, supports them, and determines the character of their activity. The results of the investigation suggests a role for MFB in the modulation of cortical epileptiform activity.

Key Words

“penicillin” epileptiform focus medial forebrain bundle preoptic region hyperactive determinant dispatch station cerebral cortex 


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Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • G. N. Kryzhanovskii
    • 1
  • V. V. Ruseev
  • V. I. Ivanov
  1. 1.Academy of Medical Sciences of the USSRUSSR

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