Changes in the hypothalamic nuclei in in experimental allergy

  • D. E. Al'pern
  • E. V. Sidorenko
Morphology and Pathomorphology


In rabbits subjected to prolonged sensitization and in which the Arthus phenomenon was induced there was a marked reaction of the hypothalamic nuclei. Staining by Gomori's method indicated a cellular swelling, loss of granules, and protoplasmic vacuolization in the supraoptic nucleus. There was a considerable increase in the size of the cross-sectional area of the cells. The same effects were much less well shown in the paraventricular nucleus. These results show that marked signs of increased neurosecretion developed in the animals at the height of the Arthus phenomenon.


Public Health Considerable Increase Paraventricular Nucleus Marked Sign Hypothalamic Nucleus 
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Copyright information

© Consultants Bureau Enterprises, Inc. 1964

Authors and Affiliations

  • D. E. Al'pern
    • 1
  • E. V. Sidorenko
    • 1
  1. 1.Department of Pathological Physiology and Department of HistologyKhar'kov Medical InstituteKhar'kovUSSR

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