Tolerance of mice at different ages to muscarine-and nicotine-like cholinolytics
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An inquiry was made into the tolerance of mice, aged 2–3 days, 2 weeks, 3–4 weeks, and adult mice to cholinolytics, atropine, tropacine, difacil, amisil, amisil methylate, pachycarpine and hexonium. It was shown that the differences in the tolerance of mice to these compounds depended on their capacity to block the M- or N-cholinoreactive systems. Nitrogen charge in the molecule was of lesser significance. Mice of younger age groups were less tolerant to M-cholinolytics, and more so to N-cholinolytics, than adult animals.
KeywordsPublic Health Nitrogen Methylate Atropine Adult Mouse
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