Treatment of blood transfusional shock superimposed on the action of neuroplegic drugs

Summary

Experiments were made on 24 dogs. Fresh citrate rabbit blood given in a dose of 5 ml/kg of body weight was used as a shock-producing factor. Blood pressure level and the character of respiration served as shock indices. The initial maximal blood pressure averaged 146 mm Hg, the minimal one 132 mm Hg. Intravenous administration of rabbit blood against the background of preliminary action of ganglioblockers led to development of hemotransfusional shock with a marked drop of the maximal and minimal blood pressure. The animals recovered from shock hypotension following the intravenous injection of toad toxin and adrenalin. As established, ganglioblocking preparations, given in the combination and dosage prescribed, did not protect the organism from hemotransfusional shock. Administration of the toad-skin gland secretion against the background of the ganglioblocking preparations action led to recovery from the hemotransfusional shock by increasing the blood pressure. The efficacy of adrenalin action on the blood pressure is greater than that of the toad toxin.