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Connection between the increased fibrinogen concentration in dogs with radiation sickness and the fibrinogenase activity

  • Pathological Physiology and General Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

A study was made of the concentration of blood plasma fibrinogen in relation to the changes of fibrinogenase activity. Dogs with radiation sickness (severe, moderately severe, and mild) served as experimental animals. A rise of the blood plasma fibrinogen content was observed in dogs with severe and moderately severe radiation sickness.

This phenomenon is especially pronounced at the height of radiation sickness. The activity of fibrinogenase in severe radiation sickness was considerably decreased at the initial period and at the height of the disease. The rise of fibrinogen content in severe and moderately severe radiation sickness should be regarded as an adaptive reaction directed to control hemorrhages, not as the sequence of reduced fibrinogenase activity.

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Authors and Affiliations

  1. Order of Lenin S. M. Kirov Military Medical Academy, Leningrad

    K. V. Gordeeva

Authors
  1. K. V. Gordeeva
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Gordeeva, K.V. Connection between the increased fibrinogen concentration in dogs with radiation sickness and the fibrinogenase activity. Bull Exp Biol Med 54, 1221–1223 (1963). https://doi.org/10.1007/BF00785591

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  • DOI: https://doi.org/10.1007/BF00785591

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