Summary
A study was made of the ACTH content in the hypophyses of rats aged 1, 3, 12, and 24 months. Determinations were conducted on the basis of increased production of corticosteroids by the adrenal glands of test animals in vitro on addition to the incubation medium of the extracts of hypophyses obtained from experimental animals. As established, the content of ACTH shows a constant increase with advancing age in the whole hypophysis. However, the content of ACTH, as calculated per unit of body weight, remains unchanged (at least beginning from the age of 3 months). The concentration ACTH, as calculated per unit of raw weight of hypophysis tissue, does not change with the progress of age.
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Blok, L.N. Concentration of acth in the hypophysis of rats at different ages. Bull Exp Biol Med 54, 1206–1209 (1963). https://doi.org/10.1007/BF00785587
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DOI: https://doi.org/10.1007/BF00785587