Bulletin of Experimental Biology and Medicine

, Volume 82, Issue 2, pp 1262–1265 | Cite as

Morphohistochemical study of the rat placenta after exposure to carbon tetrachloride at different stages of pregnancy

  • N. I. Tsirel'nikov
  • T. G. Tsirel'nikova
Morphology and Pathomorphology


Intraventricular injection of CCl4 (0.3 ml/100 g body weight) into female rats causes marked injury to the tissues of the placenta and, in particular, to the chorionic epithelium of the labyrinthine portion, with maximal development of degenerative and necrobiotic changes on the 14th–16th day of pregnancy (if the poison is injected 48 h before sacrifice). An increase in the number of mitotically dividing epithelial cells is observed at all times and the dimensions of the nuclei and nucleoli of the cytotrophoblastic cells are increased on the 17th–18th day of intrauterine development of the fetus. Injection of CCl4 leads to a decrease in the content of histochemically detectable glycogen in the cytoplasm of the chorionic epithelium and a decrease in the content of amylase-resistant glycoproteins, protein, and RNA in the degenerating cells.

Key Words

Placenta CCl4 necrobiotic changes 


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Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • N. I. Tsirel'nikov
  • T. G. Tsirel'nikova

There are no affiliations available

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