Abstract
The degree of affinity of steroids of the estrone series for the estradiol-binding system of the guinea pig uterus was analyzed. The factor determining interaction with the receptor system of the guinea pig uterus was found to be the presence of free hydroxyl groups in positions 3 (phenol) and 17β and their mutual orientation. The results suggest that the biological activity of steroids is determined by the character of their structural interaction with the receptor systems of the uterus.
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Shchedrina, R.N., Sturchak, S.V., Bobrova, E.G. et al. Specificity of the estradiol-binding system of the guinea pig uterus. Bull Exp Biol Med 82, 1239–1243 (1976). https://doi.org/10.1007/BF00785569
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DOI: https://doi.org/10.1007/BF00785569