Bulletin of Experimental Biology and Medicine

, Volume 82, Issue 2, pp 1186–1187 | Cite as

Effect of exogenous DNA on content and biosynthesis of endogenous DNA in rat bone marrow

  • V. B. Shorokhova
Biochemistry and Biophysics

Abstract

The effect of exogenous DNA on the content and rate of biosynthesis of endogenous DNA in rat bone marrow was studied. After injection of high-polymer homologous DNA into intact rats the endogenous DNA content per gram bone marrow was found to be reduced for the first 3 days (the decrease was most marked after 3 days, namely by 36%) and it returned to normal by the 6th day. The rate of DNA biosynthesis in rat bone marrow was increased after 18 h (when it was twice as high as in the control) and after 6 days (by 58%), and it was close to normal again 1–3 days after injection of DNA.

Key Words

Exogenous DNA bone marrow rate of DNA biosynthesis 

Literature Cited

  1. 1.
    V. M. Luzanov, Byull. Éksp. Biol. Med., No. 10, 94 (1974).Google Scholar
  2. 2.
    V. K. Mazurik and E. Yu. Moskaleva, Byull. Éksp. Biol. Med., No. 2, 32 (1974).Google Scholar
  3. 3.
    S. A. Rogacheva, G. G. Rusinova, and É. G. Sharova, Tsitologiya, No. 7, 912 (1970).Google Scholar
  4. 4.
    P. F. Rokitskii, Fundamentals of Statistics for Biologists [in Russian], Minsk (1961).Google Scholar
  5. 5.
    G. G. Rusinova, Biokhimiya, No. 5, 889 (1971).Google Scholar
  6. 6.
    A. S. Spirin, Biokhimiya, No. 5, 656 (1958).Google Scholar
  7. 7.
    E. R. M. Kay, Nature,191, 387 (1961).Google Scholar
  8. 8.
    G. Schmidt and S. J. Thannhauser, J. Biol. Chem.,161, 83 (1945).Google Scholar

Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • V. B. Shorokhova

There are no affiliations available

Personalised recommendations