Bulletin of Experimental Biology and Medicine

, Volume 82, Issue 2, pp 1186–1187 | Cite as

Effect of exogenous DNA on content and biosynthesis of endogenous DNA in rat bone marrow

  • V. B. Shorokhova
Biochemistry and Biophysics


The effect of exogenous DNA on the content and rate of biosynthesis of endogenous DNA in rat bone marrow was studied. After injection of high-polymer homologous DNA into intact rats the endogenous DNA content per gram bone marrow was found to be reduced for the first 3 days (the decrease was most marked after 3 days, namely by 36%) and it returned to normal by the 6th day. The rate of DNA biosynthesis in rat bone marrow was increased after 18 h (when it was twice as high as in the control) and after 6 days (by 58%), and it was close to normal again 1–3 days after injection of DNA.

Key Words

Exogenous DNA bone marrow rate of DNA biosynthesis 

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Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • V. B. Shorokhova

There are no affiliations available

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