Bulletin of Experimental Biology and Medicine

, Volume 82, Issue 2, pp 1154–1157 | Cite as

Effect of acute hypoxia in the antenatal period on functions of the higher levels of the CNS in rats

  • A. L. Zabludovskii
  • M. Ya. Maizelis
  • R. I. Kruglikov
Pathological Physiology and General Pathology


A decrease in motor activity, depression of the orienting reflex, and its faster extinction than in control animals were observed in sexually mature rats exposed to acute hypoxia in the antenatal period. Disturbances of conditioned reflex activity indicating impairment of fixation of the temporary connection, weakening of inhibition, and lowering of the mobility of nervous processes were discovered in the experimental rats. When tests involving “difficult” tasks were presented the experimental rats developed epiliptiform seizures. An increase in predisposition to seizures also was observed after administration of threshold doses of metrazol.

Key Words

Intrauterine hypoxia brain higher nervous activity 


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Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • A. L. Zabludovskii
  • M. Ya. Maizelis
  • R. I. Kruglikov

There are no affiliations available

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