Effect of adaptation to high-altitude hypoxia in early ontogeny on higher nervous activity
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Newborn male and female Wistar rats were adapted to hypoxia in a pressure chamber. Adaptation began at an “altitude” of 1000 m for 1 h daily, after which the duration and intensity of exposure were gradually increased so that, starting from the 17th day, the animals were adapted to an altitude of 5000 m for 5 h on 5 days a week. After adaptation for two months, a conditioned active avoidance reflex was produced in the animals. In the adapted males a tendency was observed for the reflex to be formed more rapidly and for it to be preserved to a much greater degree than in the control animals. In females adapted to hypoxia under similar conditions no changes were observed in the formation and preservation of the reflex.
Key WordsAdaptation hypoxia conditioned reflexes
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