Summary
Fasting for 24 hours did not change the number of dividing cells of the corneal epithelium in rats with the average weight of 55–60 g, whereas 48-hour fasting was accompanied by its intensification; mitotic activity was found to be considerably reduced after 72 hr of the experiment. After an initial rise, observed for up to 72 hr of fasting, the mitotic activity was found to decrease on the 4th, 5th, 6th, and 7th days in rats with an average weight of 157 g. The maximal reduction of mitotic activity (34%) and of the body weight (35%) was revealed on the 7th experimental day.
In rats with average weight of 332 g the mitotic activity increased by 13% on the average (as compared with controls) during fasting from 2 to 7 days. Reduction in the number of dividing cells in this weight group was noted after 9 days of fasting. The most rapid reduction of the weight and mitotic activity occurred in rats with the least weight. In medium-weight and high-weight rats such changes took place later. Intensification of metabolism in the fasting animals, connected with the increased energy expenditure for replenishment of thermal requirements (with the animals kept at 16°C) produced maximal reduction of mitotic activity and the greatest loss of weight in the smallest rats.
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Movchan, O.T. Relationship between changes in mitotic activity of the corneal epithelium and body weight of fasting animals. Bull Exp Biol Med 50, 1317–1321 (1961). https://doi.org/10.1007/BF00785393
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DOI: https://doi.org/10.1007/BF00785393