On the mechanism of compensatory diuresis following unilateral nephrectomy in dogs
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The antidiuretic activity of blood plasma in dogs was studied (by means of tests on rats) prior to, and 1–2 hours after unilateral nephrectomy. The antidiuretic activity of dog plasma declines directly after the operation. The blood plasma obtained from dogs prior to the operation inhibits the excretion of water load in the rats.
Changes in the antidiuretic activity of blood plasma are regarded as being the result of the reflex effects from the vascular and tissue osmoreceptors in connection with increased amounts of extracellular water, directly after nephrectomy. It is therefore concluded that reduction of the plasma antidiuretic activity is an important factor in the mechanism of diuresis compensation directly after unilateral nephrectomy.
KeywordsPublic Health Blood Plasma Water Load Extracellular Water Unilateral Nephrectomy
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