Summary
It has been established that rabbits possess an increased sensitivity to antibiotics of the tetracycline group. On administering chlortetracycline, tetracycline, or oxytetracycline to rabbits per os in doses of from 5 to 50 mg/kg per day the majority of the animals died within 2 weeks after initiation of the treatment, with phenomena of increasing apathy, anorexia, weight reduction and profuse diarrhea.
Large numbers ofB. proteus appeared in the intestinal contents of rabbits which received tetracyclines.
Leukocytosis was noted in the blood due to the increase in the number of polymorphonuclear segmented neutrophils and relative lymphocytopenia was also present.
The most pronounced pathological-anatomical changes resulting from tetracycline administration to rabbits were observed in the gastrointestinal tract.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
A. M. Kharitonova, Antibiotiki, 2, No. 4, 46 (1957).
P. Ambrosioni, S. Masoni, Boll. ist. sieroterap. (Milan, 1955) v. 34, p. 408.
P. Ambrosioni and S. Masoni, Boll ist, sierotrap. (Milan, 1955) v. 34, p. 418.
C. M. Ambrus, C. N. Sideri, et al., Antibiot and Chemother. 1955, v. 5, p. 521.
G. W. Fischer, zentr. Bakt. 1955, v. 164, p. 230.
E. Koch, H. Bohn, and oth., Arch. exper. Path. u. Pharmakol., 1953, v. 220, p. 157.
E. Ruschmann, Zbl. Hyg. u. Infektionskr., 1954, zentr. Hyg u. Infektionskr, 1954, v. 140, p. 333.
P. De Somer, H. van de Voorde, and H. Eyssen, et al., Antibiotics and Chemother. 1955, v. 5, p. 413.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kiyman, G.Y., Chumachenko, N.V., Somol'nikova, N.M. et al. The hypersensitivity of rabbits to the tetracyclines. Bull Exp Biol Med 48, 1238–1241 (1959). https://doi.org/10.1007/BF00785180
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00785180