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The effect on erythropoiesis of serum from healthy and anemic subjects

Communication 1. Changes in the blood and bone marrow

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

A subcutaneous injection of 3 ml of serum of patients suffering from acute posthemorrhagic anemia and from pernicious anemia provokes an increase in the number of reticulocytes in healthy rabbits. Not only is there a peripheral reticulocytosis, but there is also an increase in the number of reticulocytes and erythroblasts in the bone marrow.

The serum of some patients suffering from iron deficiency anemia possesses the same property, but the effect occurs less regularly than in the groups mentioned previously.

Some of the healthy persons has no effect on the number of reticulocytes. Possibly there is an increased production of erythropoetins in some forms of anemia.

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Authors and Affiliations

  1. Laboratory of the Physiology of Circulation, AN SSSR I. P. Pavlov Institute of Physiology, Leningrad, USSR

    S. Yu. Shekhter & A. Ya. Yaroshevskii

  2. Teaching Clinic of Internal Diseases, I. P. Pavlov I Leningrad Medical Institute, Leningrad, USSR

    S. Yu. Shekhter & A. Ya. Yaroshevskii

Authors
  1. S. Yu. Shekhter
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  2. A. Ya. Yaroshevskii
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Shekhter, S.Y., Yaroshevskii, A.Y. The effect on erythropoiesis of serum from healthy and anemic subjects. Bull Exp Biol Med 48, 1205–1208 (1959). https://doi.org/10.1007/BF00785171

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  • DOI: https://doi.org/10.1007/BF00785171

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