Summary
The experiments were performed on cats. The ileocecal portion of the intestine in which only the nervous connection with the rest of the body were left intact was perfused. Preliminary introduction of 1 ml of 1∶105–1∶104 acetylcholine into the perfusate causes an increase in the reflex changes in respiration and arterial pressure induced by stimulation of the mechanoceptors of the isolated portion of intestine.
The same effect was observed when the perfused area had been atropinized prior to giving the acetylcholine and stimulating mechanically.
The results show that acetylcholine has a sensitizing effect on mechanoceptors.
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Dzheliev, I.T., Chernigovskii, V.N. Sensitization of mechanoceptors by acetylcholine. Bull Exp Biol Med 48, 1183–1186 (1959). https://doi.org/10.1007/BF00785165
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DOI: https://doi.org/10.1007/BF00785165