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The study of different methods of cell division in two transplantable lines of normal and malignant human cells

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

A study was made of modes of division of human cancer cells—HeLa strain—and of human amnion cells with the use of monolayer cultures in synthetic medium “199” with added calf serum. The mitotic, amitotic and nuclear gemmation coefficients were determined during the 7 days of cultivation.

A prevalence of mitotic division over amitosis and nuclear gemmation was noted during the first days of cultivation of amniotic cells, and on the 4th day cultivation of HeLa cells. On the 5th day, amitosis and nuclear gemmation were the prevailing forms of multiplication in the 2 cell strains.

The mitotic coefficient of the HeLa cells decreased by the 7th day; amitosis, as well as solitary and multiple budding of the nucleus proved to be the prevailing form in the 2 strains of cells.

Reduction of mitotic coefficient of the amniotic cells during the same period of cultivation was not so marked, but the prevalence of amitosis and nuclear budding was largely of the same character as in the HeLa cell cultures.

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Authors and Affiliations

  1. Group of Experimental Cell Morphology, Institute of Experimental Biology of the AMN SSSR, Moscow

    I. A. Glinskii

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  1. I. A. Glinskii
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Glinskii, I.A. The study of different methods of cell division in two transplantable lines of normal and malignant human cells. Bull Exp Biol Med 58, 1219–1222 (1964). https://doi.org/10.1007/BF00785013

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  • DOI: https://doi.org/10.1007/BF00785013

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