Bulletin of Experimental Biology and Medicine

, Volume 58, Issue 4, pp 1199–1203 | Cite as

Action of tetanus toxin on neuromuscular transmission

  • G. N. Kryzhanovskii
  • A. Kh. Kasymov
Pharmacology
  • 18 Downloads

Summary

Comparison of the effects produced by tetanus toxin and proserine (neostigmine) demonstrated in experiments on cats that tetanus toxin was not a cholinesterase inhibitor. There exists a functional antagonism between the action of the tetanus toxin and that of proserine. At the same time, functional synergism was found to exist between the action of the toxin and that of d-paracurarine as evidenced by the fact that curare block developed more rapidly in the toxin-poisoned muscle than in the normal one. With increase of intoxication periods there was a drop in the action potential amplitude in the muscle, and curare block developed more rapidly. A characteristic response of the intoxicated muscle to indirect rhythmic stimulation with a fairly high frequency (pessimal for the normal muscle) was an increase in the action potential during the initial stimuli, and a relative maintenance of its value during the later stimuli.

The results of this work permit a conclusion that tetanus toxin disturbs the neuromuscular transmission. The possible mechanisms of this effect are discussed. It is very likely that tetanus toxin influences the excretion of the mediator by the presynaptic apparatus.

Keywords

Public Health Cholinesterase Tetanus Characteristic Response Neostigmine 

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Copyright information

© Consultants Bureau 1965

Authors and Affiliations

  • G. N. Kryzhanovskii
    • 1
  • A. Kh. Kasymov
    • 1
  1. 1.Laboratory of Infectious Nervous Pathophysiology Institute of Normal and Pathological PhysiologyAcademy of Medical SciencesMoscowUSSR

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