Bulletin of Experimental Biology and Medicine

, Volume 58, Issue 4, pp 1138–1140 | Cite as

Conditioned-reflex changes in respiratory arrhythmia

  • L. A. Mirzabaeva


Chronic experiments were conducted on 2 dogs in a study of conditioned reflex activity on the respiratory arrhythmia following morphine administration. Morphine was injected subcutaneously daily for 30–35 days (0.05 g to one dog and 0.2 gm to the other). The ECG was recorded by means of a cardiocyclograph (lead 2 standard).

Fifteen to twenty min following morphine administration a marked slowing of the heart rate occurred with respiratory arrhythmia intensified more than twice.

Due to elaboration of the conditioned reflex following 30–35 morphine injections, injection of physiological saline in the same experimental conditions led to a similar slowing of the cardiac rhythm and intensification of the respiratory arrhythmia, as was the case with morphine administration. The data obtained testify to the possibility of producing conditioned reflex changes in the tone of the vagus nerve nuclei.


Public Health Heart Rate Morphine Physiological Saline Vagus Nerve 
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Copyright information

© Consultants Bureau 1965

Authors and Affiliations

  • L. A. Mirzabaeva
    • 1
  1. 1.Laboratory of Clinical PhysiologyInstitute of Normal and Pathological Physiology of the AMN SSSRMoscow

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