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General and cardiotoxic action of O-streptolysin

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

O-streptolysin has a general toxic effect and causes quick death when injected intravenously in white mice.

The cardiotoxic effect of O-streptolysin was studied in experiments on isolated hearts of frogs and cats. It was demonstrated that O-streptolysin brings about cardiac arrest and contraction of the heart muscle. However, streptococcal antigens do not give such an effect on the isolated heart. The toxic action of O-streptolysin may be neutralized by the specific immune serum. The influence of O-streptolysin on the isolated heart of immune animals differed from its action on the hearts of normal animals in a number of experiments.

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Authors and Affiliations

  1. Department of Microbiology Institute of Experimental Medicine, Acad. Med. Sci. USSR, Leningrad

    V. I. Sisenko

Authors
  1. V. I. Sisenko
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Sisenko, V.I. General and cardiotoxic action of O-streptolysin. Bull Exp Biol Med 45, 537–541 (1958). https://doi.org/10.1007/BF00784964

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  • DOI: https://doi.org/10.1007/BF00784964

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