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A 5-hydroxytryptamine from Hippophae rhamnoides as an antitumor preparation in experiments on animals

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

5-hydroxytryptamine was recently isolated from the bark ofHippophae rhamnoides by G. P. Men'shikov and M. F. Petrova. The results of investigation of the action of the hydrochloride of the alkaloid upon the organism and tumors of mice and rats are presented. The preparation was named hippophain. The antitumor effect of hippophain is characterized by a wide range of action, the preparation inhibiting the growth of 7 out of 9 animal tumors (various types). However, the tumors do not resolve completely. Hippophain exercised no antitumor effect when administered per os.

The side effects of the preparation are connected with action upon the cardiovascular and respiratory systems.

The effects of a large dose of the preparation (20 mg/kg) upon hemopoiesis was studied during a 2-week treatment of sarcoma 45.

A moderate leukocytosis in the peripheral blood was observed under the action of hippophain. The absolute number of neutrophils per 1 mm3 of the blood increases by 70% in comparison with the initial level (without any shift to the left) whereas the number of lymphocytes is slightly reduced.

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Authors and Affiliations

  1. Laboratory of Experimental Chemotherapy of the Institute of Experimental and Clinical Oncology of the AMN SSSR, Moscow

    E. Ch. Pukhal'skaya, M. F. Petrova & G. P. Men'shikov

  2. Laboratory of the Chemistry of Natural Substances of the Institute of Experimental and Clinical Oncology of the AMN SSSR, Moscow

    E. Ch. Pukhal'skaya, M. F. Petrova & G. P. Men'shikov

Authors
  1. E. Ch. Pukhal'skaya
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  2. M. F. Petrova
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  3. G. P. Men'shikov
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Pukhal'skaya, E.C., Petrova, M.F. & Men'shikov, G.P. A 5-hydroxytryptamine from Hippophae rhamnoides as an antitumor preparation in experiments on animals. Bull Exp Biol Med 50, 1076–1080 (1961). https://doi.org/10.1007/BF00784884

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  • DOI: https://doi.org/10.1007/BF00784884

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