Summary
Removal of the adrenals in adult rats markedly prolongs the lateral posture induced by the intraperitoneal injection of hexenal; in one-month-old rats, the removal of the adrenals exerts no such effect. After the intraperitoneal injection of 200 γ of medinal per g of body weight, spectrography revealed a high medinal content in the brains of the newly born and one-weekold rats; in two-week-old rats, the content of medinal in the brain decreases, and after 3–4 weeks, it reaches the level observed in adult rats. The greater penetration of medinal into the brain of very young rats is believed to be due to the underdevelopment of the hypothalamohypophyseal-adrenal system. These data shed light on the earlier investigations: after three weeks of life the sensitivity of rats to medinal becomes equal to the tolerance of the adult animals, and from the same age, injections of ACTH begin to shorten the duration of barbiturate narcosis.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
I. V. Markova, Byull. Éksp. Biol. Med.47, 3, 57 (1959). Original Russian pagination. See C. B. translation.
I. V. Markova, in: Transactions of the IX Convention of the All-Union Society of Physiologists, Biochemists and Pharmacologists [in Russian] (1959), Vol. 2, p. 172.
I. V. Markova, Fiziol. Zhur.68, 12, 1485 (1959).
G. L. Mednik, Problemy Endokrinol. i Gormonoterap.3, 2, 40 (1957).
T. N. Reshtnikova, Author's Abstract of Candidate's Dissertation: The Features of Barbiturates' Effect on Young Animals [in Russian] (Tashkent, 1956).
L. S. Shtern, in: The Blood-Brain Barrier [in Russian] (Moscow, 1935).
I. A. Eskin, Pat. Fiziol. i Éksp. Terap.1, 4, 10 (1957).
L. Bakay, in: Blood-Brain Barrier (Springfield, Illinois, USA, 1956).
H. W. Deane, in Collection: Adrenal Function in Infants and Children. A symposium N. J. (London, 1954) No. 4.
H. H. Donaldson, J. Compar. Neurology and Psychol.26, 2, 119 (1910).
F. Eichholtz, R. Hotovv, E. Collischonn and H. Kauer, Arch. Exp. Path. and Pharmakol.207 5, 397 (1949).
E. Endröczi, J. Szalay and K. Lissak, Endokrinologie,34, 5–6, 331 (1957).
S. Goldschmidt, W. Lamprecht and E. Helmreich, Z. f. Physiol. Chemie292, 3–5, 125 (1953).
A. Komiya and K. Shibata, J. Pharm. and Exp. Therap.117, 1, 68 (1956).
L. C. Mark, J. J. Burns, L. Brand, C. I. Campomanes, N. Trousof, E. M. Papper and B. B. Brodie, J. Pharm. and Exp. Therap.,123, 1, 70 (1958).
L. C. Mark, J. J. Burns, C. I. Campomanes, S. H. Ngai, N. Trousof, E. M. Papper and B. B. Brodie, J. Pharm. and Exp. Therap.119, 1, 35 (1957).
V. Menkin, Am. J. Physiol.129, 3, 691 (1940).
K. Milkovic and S. Milkovic, Endokrinologie,37, 5–6, 301 (1959).
D. M. Woodbury, Pharmacological Reviews110, 2, 275 (1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Markova, I.V. Age sensitivity to barbiturates and its dependence on the development of the hypophyseal-adrenal system. Bull Exp Biol Med 50, 1060–1063 (1961). https://doi.org/10.1007/BF00784880
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00784880