Summary
Deoxyribonucleoprotein (DNP) obtained from isolated cellular nuclei of chick embryos as well as the DNP of the liver of adult hens and rats contained 40% of DNA (the ratio DNA/arginine being 5.0–5.5 with 0.8–0.9 moles of diamino acids per atom of DNA phosphorus). Tumor DNP's differed in having a higher content of DNA and a lower percentage of arginine. In two samples with low viscosity and probably degraded, the DNA and diamino acidcontent was particularly high, which stresses the dependence of the composition of the DNP on the conditions under which it is obtained.
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Literature Cited
G. P. Georgiev, L. P. Ermolaeva, and I. B. Zbarskii, Biokhimiya25, 2, 318 (1960).
A. L. Dounce, in: Contemporary Problems of Cytology [in Russian] (Moscow, 1955) p. 51.
S. S. Debov, Biokhimiya16, 4, 314 (1951).
S. S. Debov, in: Problems of Medical Chemistry [in Russian] (Moscow, 1953) Vol. 6, p. 117.
I. B. Zbarskii, in: Progress of Biological Chemistry [in Russian] (Moscow, 1950) Vol. 1, p. 91.
I. B. Zbarskii, in: Problems of Clinical and Experimental Oncology [in Russian] (Stalingrad, 1957) Vol. 2, p. 96.
I. B. Zbarskii in: Malignant Neoplasms [in Russian] (Moscow, 1959) p. 54.
I. B. Zbarskii, and G. P. Georgiev, Biokhimiya24, 2, 192 (1959). Original Russian pagination. See C. B. translation.
I. B. Zbarskii, and L. P. Ermolaeva, Biokhimiya25, 1, 114 (1960). Original Russian pagination. See C. B. translation.
L. A. Zil'ber, V. B. Freiman, I. B. Zbarskii, et al., Doklady Akad. Nauk SSSR65, 1, 97 (1949).
S. B. Manoilov, in: The Problem of the Nature of Nucleoproteins of Normal Tissues and Malignant Tumors, Doctoral Dissertation [in Russian] (Leningrad, 1951).
K. A. Perevoshchikova, in: Problems of Medical Chemistry [in Russian] (Moscow, 1953) Vol. 6, p. 125.
S. M. Saidov, Byull. Éksp. Biol. Med45, 1, 45 (1958). Original Russian pagination. See C. B. translation.
J. A. V. Butler, and P. F. Davison in: Advances in Enzymology (New York, 1957) Vol. 18, p. 16.
H. J. Cruft, C. M. Mauritzen, and E. Stedman, Philos Tr. Roy. Soc. London. Ser. B.,241, 678, 93 (1957).
P. F. Davison, and J. A. V. Butler, Biochem. et biophys. acta21, 568 (1956).
Y. Khouvine, and F. Baron, Grégoire, et al., Bull. Soc. chim. biol.36, 31 (1954).
R. M. S. Smellie, H. M. Keir, and E. D. Gray, et al., Biochem. J.72, 17, (1959).
C. Vendrely, A. Knobloch, and R. Vendrely, Biochim. et. biophys. acta.19, 472 (1956).
C. Vendrely, A. Knobloch, and R. Vendrely, Compt. rend. Acad. Sci.246 3128 (1958).
R. Vendrely, and C. Vendrely, Experientia4, 434, (1948).
R. Vendrely and C. Vendrely, Compt. rend. Acad. Sci.235, 395, (1952).
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Zbarskii, I.B., Ermolaeva, L.P. The characteristics of the nuclear nucleoproteins of some experimental tumors and of chick embryos. Bull Exp Biol Med 50, 1039–1041 (1961). https://doi.org/10.1007/BF00784875
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DOI: https://doi.org/10.1007/BF00784875