Skip to main content
SpringerLink
Log in

The effect of stereoisomers of cycloserine on the formation and transformation of free γ-aminobutyric acid in brain tissue

  • Biochemistry and Biophysics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

A study was made of the effect produced by the stereoisomers of cycloserine on decarboxylization of glutamic acid and transamination of γ-aminobutyric acid with α-ketoglutaric acid in the homogenates of the rat brain at pH 7.5. As revealed. D.L-cycloserine in a concentration of 10−3 M depressed the first process by 40% and the second one by 45%. In the same conditions D-cycloserine depressed glutamic acid decarboxylation by 9%; it somewhat activated γ-aminobutyric acid transamination. A discussion is presented on the possible effect of cycloserine isomers on the content of free γ-aminobutyric acid in the brain (in vivo) following the administration of isoniazid in large doses.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature Cited

  1. R. M. Azarkh, A. E. Braunshtein, T. S. Paskhina, et al., Biokhimiya, 5, 95 (1960).

    Google Scholar 

  2. G. E. Vladimirov and I. A. Sytinskii, Uspekhi Sovr. Biol.51, 1, 3 (1961).

    Google Scholar 

  3. E. D. Byshepan, K. I. Ivanova, and A. M. Chernukh, Byull. Éksper. Biol. 8, 52 (1959).

    Google Scholar 

  4. I. S. Severina, Biokhimiya, 5, 943 (1961).

    Google Scholar 

  5. N. I. Srnol'nikova, Byull. Éksper. Biol. 8, 70 (1961).

    Google Scholar 

  6. K. W. Giri and A. N. Rao, J. Indian Inst. Sei. A., 1953, v. 35, p. 343.

    Google Scholar 

  7. A. Sklenovsky, Activ. nerv. sup. (Praha), 1959, v. 1, p. 210.

    Google Scholar 

  8. K. Yamada, S. Sawaki, and S. Hayami, J. Vitaminol. 1957, v. 3, p. 68.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Experimental Chemotherapy, Institute of Pharmacology and Chemotherapy of the AMN SSSR, Moscow

    R. K. Ledneva & E. D. Vyshepan

Authors
  1. R. K. Ledneva
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. D. Vyshepan
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ledneva, R.K., Vyshepan, E.D. The effect of stereoisomers of cycloserine on the formation and transformation of free γ-aminobutyric acid in brain tissue. Bull Exp Biol Med 54, 1124–1125 (1963). https://doi.org/10.1007/BF00784612

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00784612

Keywords

Search

Navigation