Bulletin of Experimental Biology and Medicine

, Volume 50, Issue 2, pp 847–851 | Cite as

The effects of general anesthetics, analgesics, and chlorpromazine on reflex reactions originating in the vessels of the pulmonary circulation

  • Z. N. Ivanova
Pharmacology
  • 13 Downloads

Summary

The results of the experiments described in this paper demonstrate that the reflex reactions to injection of a stimulating substance into the pulmonary circulation change differently under the influence of different anesthetics: Urethan “facilitates” expiration without affecting the cardiovascular component; pentobarbital tends to depress the whole reflex complex to various degrees; while hexobarbital primarily depresses the bradycardia. The bradycardia may also be reduced on account of the ganglionic blocking action of the barbiturates. Promedol, an analgesic, has a diphasic effect on the reflexes from the pulmonary vessels: It first decreases them and then intensifies bradycardia and “facilitates” expiration. In cats the first phase of the promedol effect is slight and irregular. Chlorpromazine depresses the entire reflex complex completely in rabbits, but by not more than 50% in cats.

Keywords

Public Health Pentobarbital Urethan Barbiturate Chlorpromazine 

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Copyright information

© Consultants Bureau Enterprises, Inc. 1961

Authors and Affiliations

  • Z. N. Ivanova
    • 1
  1. 1.Department of PharmacologyI. P. Pavlov First Leningrad Medical InstituteLeningradUSSR

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