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Bulletin of Experimental Biology and Medicine

, Volume 54, Issue 3, pp 965–969 | Cite as

The biochemical characteristics of the skeletal muscle of the frog in various stages of fatigue and receiving single stimuli from the nerve

  • M. V. Kirzon
  • T. A. Allik
  • S. V. Shestakov
Physiology

Summary

The content of ATP, creatine phosphate, inorganic phosphate and lactic acid was studied in the isolated frog skeletal muscle at various stages of fatique caused by single maximal stimulations of the nerve. There is no lineal alteration in the content of the substances studied during the muscle work. Before the stage of abrupt decline of contractions the ATP content remains on the initial level, whereas the quantity of creatine phosphate rapidly decreases and the content of lactic acid manifests a sharp rise. The stage of abrupt decline, characterized by deceleration of the contraction and relaxation of the muscle, is the turning point in the development of fatigue. In this stage, along with further decrease of creatine phosphate and accumulation of lactic acid, there occurs a drop in the content of ATP in comparison with the level of rest.

Keywords

Public Health Phosphate Skeletal Muscle Lactic Acid Creatine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature Cited

  1. 1.
    A. M. Alekseeva. Biokhimiya, 2, 243 (1956).Google Scholar
  2. 2.
    V. A. Belitser. Chemical Conversions in Muscle [in Russian]. Moscow-Leningrad, 1940.Google Scholar
  3. 3.
    N. E. Vvedenskii. Selected Works [in Russian], p. 47. Moscow, 1952.Google Scholar
  4. 4.
    M. V. Kirzon and Z. E. Khurges. In the book: Proceedings of the First Meeting of the Moscow Society of Physiologists, Biochemists, and Pharmacologists [in Russian], p. 110. Moscow-Leningrad, 1941.Google Scholar
  5. 5.
    M. V. Kirzon. Investigation of the Mechanism of Sympathetic Action on Skeletal Muscle and Similar Phenomena of Temporary Removal of Fatigue. Doctorate dissertation, 1948.Google Scholar
  6. 6.
    V. V. Meibaum. Biokhimiya, 4, 353 (1945).Google Scholar
  7. 7.
    N. R. Mirza. General Principles of the Process of Fatigue and Temporary Removal of Fatigue of a Single Muscle Fiber with Its Nerve Supply Intact. Author's abstract of candidate dissertation, Moscow, 1949.Google Scholar
  8. 8.
    E. A. Mishukova and L. N. Lebedeva. Vopr. Med. Khimii, 5, 369 (1956).Google Scholar
  9. 9.
    F. N. Serkov. Fiziol. Zh. SSSR, 1, 53 (1949).Google Scholar
  10. 10.
    D. L. Ferdman. The Biochemistry of Diseases of Muscles [in Russian]. Kiev, 1953.Google Scholar
  11. 11.
    N. N. Yakovlev. Essays on the Biochemistry of Sport [in Russian]. Moscow, 1955.Google Scholar
  12. 12.
    S. Barker and W. Summerson, J. biol. Chem., 1941, vol. 138, p. 535.Google Scholar
  13. 13.
    R. Block, R. Lestrange, and G. Zweig. Chromatography on Paper [Russian translation]. Moscow, 1954.Google Scholar
  14. 14.
    J. Bruemmer and B. O'Dell. J. biol. Chem., 1956, vol. 219, p. 283.Google Scholar
  15. 15.
    O. H. Lowry and J. A. Lopez. J. Biol. Chem., 1946, vol. 162, p. 421.Google Scholar

Copyright information

© Consultants Bureau Enterprises, Inc. 1963

Authors and Affiliations

  • M. V. Kirzon
    • 1
  • T. A. Allik
    • 1
  • S. V. Shestakov
    • 1
  1. 1.Department of Animal Physiology and Department of Animal BiochemistryMoscow State UniversityMoscowUSSR

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