Bulletin of Experimental Biology and Medicine

, Volume 54, Issue 3, pp 965–969 | Cite as

The biochemical characteristics of the skeletal muscle of the frog in various stages of fatigue and receiving single stimuli from the nerve

  • M. V. Kirzon
  • T. A. Allik
  • S. V. Shestakov


The content of ATP, creatine phosphate, inorganic phosphate and lactic acid was studied in the isolated frog skeletal muscle at various stages of fatique caused by single maximal stimulations of the nerve. There is no lineal alteration in the content of the substances studied during the muscle work. Before the stage of abrupt decline of contractions the ATP content remains on the initial level, whereas the quantity of creatine phosphate rapidly decreases and the content of lactic acid manifests a sharp rise. The stage of abrupt decline, characterized by deceleration of the contraction and relaxation of the muscle, is the turning point in the development of fatigue. In this stage, along with further decrease of creatine phosphate and accumulation of lactic acid, there occurs a drop in the content of ATP in comparison with the level of rest.


Public Health Phosphate Skeletal Muscle Lactic Acid Creatine 
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Copyright information

© Consultants Bureau Enterprises, Inc. 1963

Authors and Affiliations

  • M. V. Kirzon
    • 1
  • T. A. Allik
    • 1
  • S. V. Shestakov
    • 1
  1. 1.Department of Animal Physiology and Department of Animal BiochemistryMoscow State UniversityMoscowUSSR

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