Skip to main content
SpringerLink
Log in

The effect of ACTH on the development of the athüs phenomenon and on the morphological composition of the inflammatory exudate

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Arthüs phenomenon was induced in 42 rabbits by the classical method. ACTH (10–20 units) was injected into 33 of them before the injection of the booster dose of horse serum, as well as beginning from the 3rd–4th administration of sensitizing doses. In the majority of experiments Arthüs phenomenon did not develop at all, or was much weaker than in control animals.

The second group of experiments dealt with the cellular composition of the exudate in rats in experimental aseptic peritonitis caused by injecting sterile broth into the peritoneal cavity. Experimental results demonstrated that in animals which received ACTH (2.5 units) prior to broth injection the exudate was of thicker consistency and its cellular composition differed from control. Neutrophil percentage was much lower and lymphocytic phase occurred much earlier.

The data obtained indicates the effect of ACTH both on the manifestation of allergic inflammation and on the exudative reaction during usual inflammation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature Cited

  1. N. A. Ozeretskovskii. Pat. fiziol., 1, 76 (1959).

    Google Scholar 

  2. Ch'en Chia-p'ei. Vrach. delo 11, 1149 (1958).

    Google Scholar 

  3. Ch'en Chia-p'ei. The hypertonic reaction in the genesis of rheumatism. Author's abstract of Candidate dissertation, Kiev, 1959.

  4. V. J. Derbes, J. H. Dent, N. K. Weaver, et al., Proc. Soc. exp. Biol. (N. Y.), 1950, Vol. 75, p. 423.

    Google Scholar 

  5. T. F. Dougherty and G. Schneebeli, Proc. Soc. exp. Biol. (N. Y.), 1950, Vol. 75, p. 854.

    Google Scholar 

  6. M. Dworetzky, C. F. Code, and G. M. Higgins, Proc. Soc. exp. Biol. (N. Y.), 1950, Vol. 75, p. 201.

    Google Scholar 

  7. F. G. Germuth, Jr., G. A. Nedzel, B. Ottinger, et al., Proc. Soc. exp. Biol. (N. Y.), 1951, Vol. 76, p. 177.

    Google Scholar 

  8. C. T. Nelson, C. L. Fox, Jr., E. B. Freeman, Proc. Soc. exp. Biol. (N. Y.), 1950, Vol. 75, p. 181.

    Google Scholar 

  9. H. Selye, Int. Rec. Med., 1955, Vol. 168, p. 277.

    Google Scholar 

  10. M. Solotorovsky, F. J. Gregory, and H. C. Stoerk, Proc. Soc. exp. Biol. (N. Y.) 1951, Vol. 76, p. 286.

    Google Scholar 

  11. G. H. Stollerman, S. J. Rubin, and C. M. Plotz, Proc. Soc. exp. Biol. (N. Y.), 1951, Vol. 76, p. 261.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathological Physiology, I. P. Pavlov First Leningrad Medical Institute, Leningrad, USSR

    E. M. Mikhailova

Authors
  1. E. M. Mikhailova
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mikhailova, E.M. The effect of ACTH on the development of the athüs phenomenon and on the morphological composition of the inflammatory exudate. Bull Exp Biol Med 55, 521–522 (1964). https://doi.org/10.1007/BF00784407

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00784407

Keywords

Search

Navigation