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On the possibility of forming anti-antibodies and their effect on the survival of a skin homotransplant

  • Experimental Biology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

A study was made of the effect produced by anti-antibodies on the survival period of skin homotransplants. Rabbits and dogs were used to obtain the anti-antibodies.

In homotransplantation of the skin (in rabbit) the transplant sloughts off on the 7th–10th day. Rabbit immunization with a heterogeneous protein (blood serum of dog, immunized with an emulsion of organs of rabbits not subjected to skin transplantation) does not affect the period of take of the skin homotransplant. Immunization of rabbits with an antigenic complex, the composition of which consists of tissue proteins and anti-antibodies of the first order, increases the period of take of the transplanted skin graft by 3–4 times as compared to control.

An increase of the period of take of skin homotransplants of rabbits is connected with the action of anti-antibodies of the second order.

The liver, spleen and lymph nodes are of great significance not only in the appearance of the transplantation immunity, but they also may play an important role in overcoming it.

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Literature Cited

  1. G. A. Annenkov, Collected Works from the Kursk Medical Institute,2, p. 335 (1956) [in Russian].

    Google Scholar 

  2. S. D. Balakhovskii and I. S. Balakhovskii, Methods for the Chemical Analysis of Blood, Moscow (1953) [in Russian].

  3. Ya. Brubel, Eksper. zhir. (1962), 1, p. 50.

    Google Scholar 

  4. L. I. Geller, Zh. Mikrobiol., 10, 73 (1958).

    Google Scholar 

  5. N. N. Dakhina, Proceedings of the 2nd All-Union Conference on Problems of Tissue Incompatibility, Conservation and Transplantation of Tissues and Organs “Odessa”, p. 23 (1961) [in Russian].

  6. N. N. Zhukov-Verezhnikov, P. M. Chepov, M. M. Kapichnikov, et al., Eksper. zhir. (1957), 2, p. 55.

    Google Scholar 

  7. N. N. Zhukov-Verezhnikov, Problems of Transplantation and Conservation of Organs and Tissues, Moscow (1959), [in Russian].

  8. L. A. Zil'ber, Vestn. AMN SSSR, 10, p. 60 (1959).

    Google Scholar 

  9. E. A. Zotikov, Byull. éksper. biol., 7, 58 (1956).

    Google Scholar 

  10. E. A. Zotikov, Byull. éksper. biol.,12, 91 (1957).

    Google Scholar 

  11. P. M. Medvedev and L. S. Priezzheva, Problems of Transplantation and Conservation of Organs and Tissues, Moscow (1959) [in Russian].

  12. A. I. Polyak, Antibody formation in lymphoid tissue and the influence of ionizing radiation on this process, Candidate's Dissertation, Rostov-na-Dony (1961).

  13. V. E. Predtechenksii, V. M. Borovskaya, and L. T. Margolina, Manual of Laboratory Research Methods, Moscow (1950), [in Russian].

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Authors and Affiliations

  1. (Donetsk Scientific Research Institute of Traumatology and Orthopedics), Donetsk, USSR

    L. M. Okuneva

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  1. L. M. Okuneva
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Okuneva, L.M. On the possibility of forming anti-antibodies and their effect on the survival of a skin homotransplant. Bull Exp Biol Med 57, 224–227 (1964). https://doi.org/10.1007/BF00783548

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  • DOI: https://doi.org/10.1007/BF00783548

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