Bulletin of Experimental Biology and Medicine

, Volume 57, Issue 2, pp 196–198 | Cite as

The mechanism of reserpine ulcers of the stomach

  • I. S. Zavodskaya
  • B. R. Khodzhaev
Pharmacology

Summary

A dose of 10 mg/kg of reserpine caused destructive changes in the wall of the stomach, consisting of hemorrhages, erosions, and ulcers. Denervation and blocking (by means of pharmacological substances) of various links in the reflex arc failed to prevent the development of dystrophic alterations in the stomach wall subsequent to reserpine injection; however, the antiaminoxidase agent, ipraside, was effective in preventing the development of reserpine ulcers. The formation of reserpine ulcers, and the antagonism between the reserpine and ipraside action on dystrophic processes within the wall of the stomach was not connected with serotonin balance. Reserpine delayed the rate of radioactive methionine incorporation into the proteins of the stomach wall, and disturbed protein resynthesis, causing the dystrophic lesions.

Keywords

Public Health Serotonin Methionine Reserpine Stomach Wall 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    I. S. Zavodskaya, Gangliolytics and Blockaders of the Neuro-Muscular Synapses [in Russian], Leningrad (1958). p. 96.Google Scholar
  2. 2.
    A. H. Amin, T. B. B. Crawford, and J. H. Gaddum, J. Physiol. (London) (1954)126, p. 596.Google Scholar
  3. 3.
    I. G. Blackmann, D. S. Campion, and F. N. Fastier, Brit. J. Pharmacol. (1959),14, p. 112.Google Scholar
  4. 4.
    B. B. Brodie, A. Pletscher, and P. A. Shore, Science (1955),122, p. 968.Google Scholar
  5. 5.
    S. Emas, Biochem. Pharmacol. (1961),8, p. 169.Google Scholar
  6. 6.
    B. J. Haverback and D. F. Bogdanski, Proc. Soc. exp. Biol. (N. Y.) (1957),95, p. 92.Google Scholar
  7. 7.
    C. Hedinger, F. Veraguth, and F. Veraguth, Schweiz. med. Wschr. (1957),87, p. 1175.Google Scholar
  8. 8.
    S. Udenfriend, H. Weissbach, and D. F. Bogdanski, J. Pharmacol. exp. Ther. (1957),120, p. 255.Google Scholar

Copyright information

© Consultants Bureau Enterprises, Inc. 1964

Authors and Affiliations

  • I. S. Zavodskaya
    • 1
  • B. R. Khodzhaev
    • 1
  1. 1.Division of Pharmacology, Institute of Experimental MedicineAcademy of Medical SciencesUSSR

Personalised recommendations