The mechanism of reserpine ulcers of the stomach
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A dose of 10 mg/kg of reserpine caused destructive changes in the wall of the stomach, consisting of hemorrhages, erosions, and ulcers. Denervation and blocking (by means of pharmacological substances) of various links in the reflex arc failed to prevent the development of dystrophic alterations in the stomach wall subsequent to reserpine injection; however, the antiaminoxidase agent, ipraside, was effective in preventing the development of reserpine ulcers. The formation of reserpine ulcers, and the antagonism between the reserpine and ipraside action on dystrophic processes within the wall of the stomach was not connected with serotonin balance. Reserpine delayed the rate of radioactive methionine incorporation into the proteins of the stomach wall, and disturbed protein resynthesis, causing the dystrophic lesions.
KeywordsPublic Health Serotonin Methionine Reserpine Stomach Wall
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