Respiration and respiratory chain phosphorylation in homogenates and mitochondria of rabbit cardiac muscle during experimentally induced myocarditis
In experimental myocarditis provoked in rabbits by intravenous injection of adrenaline and theophylline, the intensity of the respiratory processes and associated phosphorylation decreased in the homogenates of cardiac muscle and isolated mitochondria in the presence of respiratory substrates added to the medium. Reduction of respiratory intensity and of phosphorylation occurs gradually and evenly, the value of P ∶ O coefficient in myocarditis thus equalling that in normal conditions. Experiments with mitochondria show that the system connected with the oxidation of the α-ketoglutaric acid is the one to be most markedly disturbed in myocarditis.
KeywordsPublic Health Normal Condition Adrenaline Theophylline Intravenous Injection
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