Summary
Acetylcholine (5–50 μg) and carbocholine (1–40 μg) administered into the lateral ventricle of the rabbit brain caused a distinct, stable picture of activation of the EEG, excitation and in a number of cases exophthalmos and bradycardia. The EEG activation was depressed and prevented by intra-venous injection of central cholinolyticsamizil and atropine and remained unchanged after intravenous administration of peripheral cholinolytic-antrenyl. Not all the mentioned cholinolytics cause changes in the animals behavior. The presence of cholinergic synapses in structures having some relation to the activation reaction was confirmed.
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Rutman, É.M. Action of acetylcholine and carbachol when injected into the cerebral ventricles. Bull Exp Biol Med 57, 6–9 (1964). https://doi.org/10.1007/BF00783462
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DOI: https://doi.org/10.1007/BF00783462