Bulletin of Experimental Biology and Medicine

, Volume 59, Issue 3, pp 333–336 | Cite as

A simplified method of determining the degree of regurgitation of blood through incompetent valves from dye-dilution curves

  • R. S. Vinitskaya


A formula has been derived for the simplified estimation of blood regurgitation through incompetent heart valves from the dye-dilution curve (methylene blue injected intravenously) recorded by an auricular oxyhemograph. The degree of regurgitation as a percentage of the total blood-flow is expressed as a relation of the “ideal” curve area to an area limited by the actual curve. The “ideal” curve may be plotted on the assumption that with normal nemodynamics the time on the stain curve form its appearance in the ear to the extrapolated moment of complete disappearance is on the average 2.7 times longer than that from the appearance of the stain to the maximum concentration.

With a small risk of error, the figure delineated by the stain dilution curve may be assumed to be a triangle. This renders the calculation simpler, and as a result the percentage of the blood black flow is determined from the formula\(\frac{{OE^1 - 2.7EM}}{{EO^1 }} \cdot 100\% \); where, EO1 is the actual time on the entire curve from appearance to extrapolated moment of disappearance of the dye and 2.7 EM is the “ideal” curve time.


Public Health Methylene Maximum Concentration Methylene Blue Actual Time 
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Copyright information

© Consultants Bureau Enterprises, Inc. 1965

Authors and Affiliations

  • R. S. Vinitskaya
    • 1
  1. 1.Laboratory of PhysiologyA. V. Vishnevskii Institute of Surgery of the AMN SSSRMoscow

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