Summary
A transplantable cellular strain, CA-SV 40-63-1, was produced from a sarcoma in a Syrian hamster induced by injection of SV 40 virus. The cellular strain formed after a prolonged lag-phase. The CA-SV 40-63-1 cultures were characterized by a marked cellular polymorphism, high mitotic activity, a tremendous number of giant mono- and polynuclear cells. The administration of cells of the CA-SV 40-63-1 strain to Syrian hamsters causes the formation of sarcomas of which the cellular composition bears a striking resemblance to that of the CA-SV 40-63-1 strain. One of such tumors gave rise to a new cellular strain, CA-SV 40-63-1 bis, which formed without the lag-phase. The cytological characteristics of the 2nd cellular strain are close to those of the CA-SV 40-63-1 strain. Certain aspects of the problem of relationships between the processes of malignization of cells in vivo and transformation of cells in vitro are also discussed.
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Blumkin, V.N., Gavrilov, V.I., Vasil'eva, N.N. et al. Cell lines produced from tumors caused by virus SV 40. Bull Exp Biol Med 59, 552–556 (1965). https://doi.org/10.1007/BF00783083
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DOI: https://doi.org/10.1007/BF00783083