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Effect of various indolylalkylamines on the motor cells of mollusk embryos and the blood vessels of the rabbit ear

  • Pharmacology
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Summary

All of the studied indolylalkylamines (30 substances in all) as well as β-indazolylethylamine are capable of stimulating the embryonal motor activity of nudibranchiate mollusks. The most active in this respect is 5-hydroxytryptamine (serotonin). Combinations with substituting groups in the 2nd, 4th, 6th, or 7th position of the idol ring are less active than tryptamine. the activity is also lessened by elongation of the lateral chain (δ-3-indolylbutylamine), by inclusion of the methyl group in the α-position or by substituting nitrogen for carbon in the 2nd position of the inactive. With the formation of innervation the sensitivity of the motor cells to serotonin and tryptamine declines and to a number of other indolylalkylamine increases. A similar series of activities has been discovered in the study of the vasoconstrictive effect of indolylalkylamine on the vessels of the rabbit eat.

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Literature Cited

  1. G. A. Buznikov and B. N. Manukhin, Zh. Obshchei Biol., No. 5 (1960), p. 347.

    Google Scholar 

  2. P. G. Zherebchenko and N. N. Suvorov et al., Med. Radiol., No. 8 (1961), p. 27.

    Google Scholar 

  3. Kh. S. Koshtoyants, Problems of the Enzyme Chemistry of Processes of Excitation and Inhibition in the Evolution of the Functions of the nervous System [in Russian], Moscow (1963).

  4. G. Bertaccini and P. Zamboni, Arch. int. Pharmacodyn., 133 (1961), p. 138.

    Google Scholar 

  5. H. O. J. Collier, In book: G. R. Lewis (Ed.), 5-Hydroxytryptamine. Proceedings Symposium. London (1957, 1958), p. 5.

  6. E. Florey, Ann. Rev. Physiol, 23 (1961), p. 501.

    Google Scholar 

  7. J. H. Welsh, Ann. N. Y. Acad. Sci., 66 Art. 3 (1957), p. 618.

    Google Scholar 

  8. J. H. Welsh and A. C. McCoy, Science, 125 (1957), p. 348.

    Google Scholar 

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Authors and Affiliations

  1. Laboratory of General and Comparative Physiology Institute of Morphology, Academy of Sciences USSSR, Moscow

    G. A. Buznikov, P. G. Zherebchenko & I. V. chudakova

Authors
  1. G. A. Buznikov
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  2. P. G. Zherebchenko
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  3. I. V. chudakova
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Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 59, No. 5, pp. 59–63, May, 1965

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Buznikov, G.A., Zherebchenko, P.G. & chudakova, I.V. Effect of various indolylalkylamines on the motor cells of mollusk embryos and the blood vessels of the rabbit ear. Bull Exp Biol Med 59, 527–531 (1965). https://doi.org/10.1007/BF00783076

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  • DOI: https://doi.org/10.1007/BF00783076

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