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Effect of extensive small bowel resection on the enzyme secretory function of the stomach

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

In 9 dogs with stomachs isolated after Pavlov and Heidenhain and with stomach fistulas, a study was made on the secretion of pepsin with gastric juice in response to meat, hematogen, histamine and alcohol sham feeding with meat as well as on the pepsinogen content of the blood serum and secretion of uropepsin with 24 h urine before and after an extensive resection of the small intestine (50–70%). Following excision of the proximal portion of the small intestine in 5 dogs, the secretion of pepsin with gastric juice, the pepsinogen and uropepsin levels increased, while in 4 dogs, which had undergone resection of the distal portion of the small intestine, no substantial change in these responses was noted with regard to most of the stimulating agents. The possibility is discussed of using the determination of the pepsinogen and uropepsin content for conclusion on the enzyme-secretory function of the stomach.

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Authors and Affiliations

  1. Laboratory of Gastro-Intestinal Physiology and Pathology, Institute of Normal and Pathological Physiology, USSR Academy of Medical Sciences, Moscow

    B. I. Sabsai

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  1. B. I. Sabsai
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Sabsai, B.I. Effect of extensive small bowel resection on the enzyme secretory function of the stomach. Bull Exp Biol Med 59, 512–515 (1965). https://doi.org/10.1007/BF00783072

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  • DOI: https://doi.org/10.1007/BF00783072

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