Bulletin of Experimental Biology and Medicine

, Volume 57, Issue 4, pp 483–485 | Cite as

The effect of high ascorbic acid doses on the course of pregnancy in the guinea pig and on the progeny

  • E. P. Samborskaya
Experimental Biology


The work is a continuation of investigations made earlier by the author (Bull. of Exp. Biol. and Med. No. 10, 1962) on the effect of ascorbic acid on the function of the genital organs of female guinea pigs. This work contains data on the effect produced by ascorbic acid excess on the course of pregnancy and on the progeny.

It was shown that prolonged (during the whole course of pregnancy) daily per oral administration of ascorbic acid to female guinea pigs (high doses −500 mg per animal, and physiological doses 50 mg per animal) led to pathology of pregnancy and of the progeny.

This pathology is manifested by a considerable percentage of abortions at various periods, as well as by stillbirths and by birth of nonviable progeny. Histomorphological examination of internal organs of stillborn and nonviable animals revealed marked tissue hypoxia.


Public Health Ascorbic Acid Oral Administration Tissue Hypoxia Genital Organ 
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Literature Cited

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    G. B. Andreenko and N. P. Sytina, Byull. éksper. biol., No. 10 (1961), p. 31.Google Scholar
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    Kawakami Shuichi, Ref. zh. Biologiya, No. 19, No. 92381 (1960). 0944 0907 V 2Google Scholar
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Copyright information

© Consultants Bureau Enterprises, Inc. 1964

Authors and Affiliations

  • E. P. Samborskaya
    • 1
  1. 1.P. M. Buiko Institute of Maternity and Childhood ProtectionKiev

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