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Action of the proteinases of Clostridium oedematiens and Clostridium perfringens on homologous and heterologous toxins

  • Microbiology and Immunology
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Bulletin of Experimental Biology and Medicine Aims and scope

Summary

The author elaborated a purifying method for endoproteinases ofCl. oedematiens and Cl.perfringens by precipitation with ammonium sulfate with a subsequent treatment with chloroform and acetone and gel filtration through sefadex G-50. The action of proteinases on partially purified homologous and heterologous toxins was accompanied by a marked drop of toxicity (titration in vivo and in vitro — on tissue culture of chick embryo). Trypsin action on the toxins studied was analogous to the effect produced byCl. oedematiens andCl. perfringens endoproteinases with a simultaneous splitting of a considerable proportion of proteins.

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Literature Cited

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  2. S. D. Elliott, J. exp. Med., Vol. 81 (1945), p. 573.

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Authors and Affiliations

  1. Division of Wound Infections, N. F. Gamaleya Institute of Epidemiology and Microbiology, AMN SSSR, Moscow

    G. F. Shemanova, E. V. Vlasova & S. A. Shamraeva

Authors
  1. G. F. Shemanova
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  2. E. V. Vlasova
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  3. S. A. Shamraeva
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Shemanova, G.F., Vlasova, E.V. & Shamraeva, S.A. Action of the proteinases of Clostridium oedematiens and Clostridium perfringens on homologous and heterologous toxins. Bull Exp Biol Med 57, 457–460 (1964). https://doi.org/10.1007/BF00782514

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  • DOI: https://doi.org/10.1007/BF00782514

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