Changes in urine excretion after injection of epinephrine in the renal artery

Summary

In acute experiments on dogs a study was made of the effect produced by adrenalin on the urine secretion following administration of the preparation into one of the renal arteries; the second kidney served as control. As established, low adrenalin doses (0.02–0.05 μg/kg/min) stimulated urine secretion mainly at the expense of increased filtration; a dose of 0.3–1 μg/kg/min adrenalin inhibited the diuresis, decreasing filtration and intensifying water reabsorption in the tubules. The action of adrenalin on the kidney was eliminated by dihydroergotamine and large aminazine doses. Low doses of ephedrine increased diuresis at the expense of depressed water reabsorption in the tubules; similarly to adrenalin high doses of the preparation inhibited the diuresis.