Summary
An investigation was made of behavior reactions of rats under the effects of benactyzine and phenamine, along with the influence exerted by adrenergic blocking agents upon the motor excitation, produced by these preparations. Chlorpromazine was effective in fully eliminating disturbed behavior reactions produced by benactyzine, dihydroergotamine, benzolin (prescolin) while sympatholytin—did this only partially. Under the effect of amphetamine all of the adrenergic blocking agents were capable of restoring the latent reflex period; but stereotype reactions, produced by the action of amphetamine, could be abolished only by chlorpromazine.
The above data prove that these disturbances appearing under the effect of the glycolic acid derivatives are caused by the activation of adrenergic mechanisms of the brain.
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Literature Cited
S. S. Krylov and E. A. Snegirev, In the book: Proceeding of the Tenth Conference of Pharmacologists, Toxicologists, and Chemotherapists [in Russian], Volgograd (1962), p. 172.
B. B. Brodie, A. Pletscher, and P. A. Shore, J. Pharmacol. exp. Ther., Vol. 116 (1956), p. 9.
M. Chessin, E. R. Kramer, and Ch. C. Scott, Ibid., Vol. 119, (1957), p. 453.
L. Goldstein and C. Munoz, Ibid., Vol. 132 (1961), p. 345.
C. Munoz and L. Goldstein, Ibid., p. 354.
K. Naess and E. W. Rasmussen, Acta pharmacol. (Kbh.), Vol. 15 (1958), p. 99.
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Snegirev, E.A. Role of adrenergic mechanisms in the development of motor excitation in rats caused by benactyzine. Bull Exp Biol Med 57, 434–436 (1964). https://doi.org/10.1007/BF00782508
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DOI: https://doi.org/10.1007/BF00782508