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Potentialization of hypnotics and anesthetics by central cholinolytics

  • Biochemistry and Biophysics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Methyldiazyl, Diazyl (benacthyzine), Aprophene, Pentaphene (Parpanit), Defacyl (Trasentine), Menthyldifacyl, Tropacine, Tiphen and thioester 22, preparations pertaining to the group of central cholynolytics, can potetialize the action of hypnotics and anesthetics (chloralhydrate), Barbamyl, Hexenal and thipental). The enhanced action of hypnotics and anesthetics under the influence of the above complex esters is caused by the central cholinolytic properties of these preparations. There is a direct relationship between the degree of hypnotic potentialization and the intensity of the cholinolytic properties of these substances: The most potent central cholinolytics (Methyldiazyl, Diazyl, Pentaphene, Aprophene and Tropacine) have the strongest intensifying effect on hypnotic and anesthetic action.

Hence, central cholinolytics may be recommended for practical use in enhancing the action of hypnotics and anesthetics.

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Literature Cited

  1. S. V. Anichkov, Annual of the Institute of Experimental Medicine [in Russian] (Leningrad, 1959) p. 153.

  2. S. N. Golikov, Farmakol. i Toksikol.19, 2, 38 (1956).

    Google Scholar 

  3. P. P. Denisenko, Theses and Abstracts of the Proceedings at the 18th Conference on Problems of Higher Nervous Activity [in Russian] (Leningrad, 1958) No. 1, p. 45.

    Google Scholar 

  4. P. P. Denisenko, Abstracts of the Proceedings at the 9th Convention of the All-Union Society of Physiologists, Biochemists and Pharmacologists [in Russian] (Moscow, Minsk, 1959),3, p. 209.

    Google Scholar 

  5. S. S. Krylov, Fiziol. Zhur. SSSR41, 4, 575 (1955).

    Google Scholar 

  6. S. S. Liberman, Farmakol. i Toksikol.19, 6, 10 (1956).

    Google Scholar 

  7. M. D. Mashkovskii, Medicinal Substances [in Russian] (Moscow, 1957).

  8. M. Ya. Mikhel'son, The Physiological Role of Acetylcholine and the Search for New Medicinal Substances [in Russian] (Leningrad, 1957).

  9. D. S. Paskov, The Pharmacological Properties of the Alkaloid Nivaline as an Anticholinesterase Substance [in Russian] Author's Abstract of Doctorate Dissertation (Leningrad, 1958).

  10. N. A. Kharauzov, in: The Selective Effect of Medicinal Substances on the Central Nervous System [in Russian] (Leningrad, 1958) p. 104.

  11. D. Bovet, V. G. Longo, J. Pharmacol. and Exper. Therap.,102, 22 (1951).

    Google Scholar 

  12. E. Jacobson, E. Sonner, Acta pharmacol. et toxicol.11, 135 (1955).

    Google Scholar 

  13. E. Jacobson, E. Sonner, Acta pharmacol. et toxicol.12, 310 (1955).

    Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology of the AMN SSSR Institute of Experimental Medicine, Leningrad

    P. P. Denisenko

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  1. P. P. Denisenko
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Denisenko, P.P. Potentialization of hypnotics and anesthetics by central cholinolytics. Bull Exp Biol Med 49, 593–597 (1960). https://doi.org/10.1007/BF00782113

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  • DOI: https://doi.org/10.1007/BF00782113

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