Skip to main content
SpringerLink
Log in

The diurnal rhythm of mitotic activity in the regenerating liver during acute radiation sickness

  • Experimental Biology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

In experiments on albino rats a study was made of the 24 h thythm in the mitotic activity of hepatic cells and in the percentage of binuclear cells in the regenerating liver following a single total exposure to X-irradiation in a dose of 600 r. The finding was that at the peak of acute radiation sickness the 24 h mitotic rhythm was retained. As in the case with reparative and physiological regeneration in nonirradiated animals the peak of mitotic activity occured during the early morning hours. The mean 24 h coefficient of the cell mitotic activity (2–3 days following operation and correspondingly 5–6 days following irradiation) did not diminish as compared to control. No regularities were revealed that would suggest that during the 24 h period the number of binuclear cells in irradiated and nonirradiated rats was changed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature Cited

  1. M. T. Gololobova, Byull. éksper. biol. 3, p. 94 (1959).

    Google Scholar 

  2. P. D. Gorizontov, In the book: Transactions of the Second International Conference on the Peaceful Use of Atomic Energy [in Russian], Moscow,5, p. 43 (1959).

    Google Scholar 

  3. P. D. Gorizontov, Ter. arkh., No. 7, p. 3 (1960).

    Google Scholar 

  4. G. P. Gruzdev, Radiobiologiya, 1, p. 52 (1961).

    Google Scholar 

  5. N. V. Krasil'nikova, Byull. éksper. biol. 7, p. 96 (1963).

    Google Scholar 

  6. L. D. Liozner and Z. A. Ryabinina, Byull. éksper. biol., 5, p. 96 (1959).

    Google Scholar 

  7. L. D. Liozner and V. F. Sidorova, Byull. éksper. biol., 12, p. 93 (1959).

    Google Scholar 

  8. G. S. Sterlin and I. V. Shiffer, Byull. éksper. biol., 7, p. 87 (1963).

    Google Scholar 

  9. E. H. Betz, Materials on a Study of the Endocrine Syndrome Caused by Total-Body Irradiation of an Organism [Russian translation], Moscow (1961).

  10. C. M. Blumenfeld, Arch. Path. (1942), v. 33, p. 770.

    Google Scholar 

  11. G. M. Higgins and R. M. Anderson (1931), v. 12, p. 186.

  12. J. J. Jaffe, Ant. Rec. (1954), v. 120, p. 935.

    Google Scholar 

  13. M. E. Wilson, R. E. Stowell, and H. O. Yokoyama et al., Cancer Res. (1953), v. 13, p. 86.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Experimental Histology, Institute of Experimental Medicine, AMN SSSR, Leningrad

    V. I. Bulgak

Authors
  1. V. I. Bulgak
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bulgak, V.I. The diurnal rhythm of mitotic activity in the regenerating liver during acute radiation sickness. Bull Exp Biol Med 59, 85–87 (1965). https://doi.org/10.1007/BF00782074

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00782074

Keywords

Search

Navigation