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Peculiarities attending the resistance of the heart to local ischemic alteration in dogs of different ages

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Following ligation of the coronary artery in puppies, aged from 16–18 days, the duration of the work of the heart in conditions of open chest and extracorporeal circulation proved to be 2–3 h. There is a rise of myocardial resistance to local ischemia in puppies aged from 16 days to 2.5 months. This rise is particularly marked in animals over 2.5–3 months of age and in adult dogs.

A rise of the cardiac resistance to local ischemia coincided with the appearance of the vagus tone and increased myocardial polarization.

A decrease of myocardial resistance to local ischemia follows vagus section. Stimulation of the peripheral portion of the vagus causes a disappearance of deformed ventricular complexes and normalizes the work of the heart.

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Authors and Affiliations

  1. Laboratory of Geriatric Physiology and Pathology Institute of Normal and Pathology Physiology, AMN SSSR, Moscow

    S. I. Enikeeva

Authors
  1. S. I. Enikeeva
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Enikeeva, S.I. Peculiarities attending the resistance of the heart to local ischemic alteration in dogs of different ages. Bull Exp Biol Med 59, 36–39 (1965). https://doi.org/10.1007/BF00782060

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  • DOI: https://doi.org/10.1007/BF00782060

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