Bulletin of Experimental Biology and Medicine

, Volume 49, Issue 4, pp 364–366 | Cite as

Changes in the buffer capacity of the tissues during endocrine disorders and growth of tumors

  • M. A. Ukolova
  • L. Kh. Garkavi
Biochemistry and Biophysics


The authors studied the buffer capacity in the tissues of animals with experimentally induced endocrine disturbances and experiments M-1 and sarcoma 45 by the method of potentiometric titration with the aid of a glass electrode. An increase of the buffer capacity in all the tissues was observed following adrenalectomy. Similar changes were noted in thyroidectomy, castration and tumor growth, i.e., reduction of the buffer capacity, mainly in the skeletal muscle tissue as well as in tissues of the brain, spleen, liver and kidneys. The decrease was even more marked in animals with tumors.


Public Health Skeletal Muscle Tumor Growth Sarcoma Muscle Tissue 
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Copyright information

© Consultants Bureau Enterprises, Inc. 1960

Authors and Affiliations

  • M. A. Ukolova
    • 1
  • L. Kh. Garkavi
    • 1
  1. 1.Experimental Division of the Rostov-on-Don Research Institute of Roentgenology, Radiology and OncologyRostov on DonUSSR

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