Bulletin of Experimental Biology and Medicine

, Volume 57, Issue 3, pp 357–360 | Cite as

Effect of small doses of alloxan on regeneration of the islet tissue of the pancreas

  • L. N. Kuleshova
Oncology
  • 14 Downloads

Summary

A study was made of the reaction and reconstructive regeneration of the insular tissue of albino rat pancreas with administration of low alloxan doses (five subcutaneous injections of 5% aqueous solution of alloxan −5 mg per 100 g body weight). Preliminary short-term administration of a low alloxan dose caused no destructive changes in the insular tissue of partially pancreatectomized animals; it activated the secretory function of the beta-cells, leading to the formation of new islets by transforming the acinar tissue into isletins.

Keywords

Public Health Body Weight Aqueous Solution Subcutaneous Injection Small Dose 

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Literature Cited

  1. 1.
    G. N. Voronin, Z. P. Mikhal'skay, and A. V. Rikkl', Byull. éksper. biol.,12, 103 (1962).Google Scholar
  2. 2.
    S. M. Leites, Uspekhi sovr. biol.,29, 1, 21 (1950).Google Scholar
  3. 3.
    N. A. Naumova, Probl. éndokrinol.,1, 53 (1961).Google Scholar
  4. 4.
    G. V. Segida, Byull. éksper. biol.,11, 88 (1962).Google Scholar
  5. 5.
    L. I. Fandeev, Byull. éksper. biol.,3, 230 (1948).Google Scholar
  6. 6.
    S. A. Bencosme, Am. J. Path., Vol., 31 (1955), p. 1149.Google Scholar
  7. 7.
    D. D. Johnson, Endocrinology, Vol. 46 (1950) p. 135.Google Scholar
  8. 8.
    Idem, Vol. 47, (1950), p. 393.Google Scholar

Copyright information

© Consultants Bureau Enterprises, Inc. 1964

Authors and Affiliations

  • L. N. Kuleshova
    • 1
  1. 1.Department of Histology and Embryology AMNVoronezh Medical InstituteVoronezhUSSR

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