Bulletin of Experimental Biology and Medicine

, Volume 57, Issue 3, pp 357–360 | Cite as

Effect of small doses of alloxan on regeneration of the islet tissue of the pancreas

  • L. N. Kuleshova


A study was made of the reaction and reconstructive regeneration of the insular tissue of albino rat pancreas with administration of low alloxan doses (five subcutaneous injections of 5% aqueous solution of alloxan −5 mg per 100 g body weight). Preliminary short-term administration of a low alloxan dose caused no destructive changes in the insular tissue of partially pancreatectomized animals; it activated the secretory function of the beta-cells, leading to the formation of new islets by transforming the acinar tissue into isletins.


Public Health Body Weight Aqueous Solution Subcutaneous Injection Small Dose 
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Copyright information

© Consultants Bureau Enterprises, Inc. 1964

Authors and Affiliations

  • L. N. Kuleshova
    • 1
  1. 1.Department of Histology and Embryology AMNVoronezh Medical InstituteVoronezhUSSR

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