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Experimental ovarian tumors in rats

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Estrogen-active tumors of the ovaries, differing in histological structure, were obtained in rats as a result of depression of ovarian function by X-irradiation, by transplantation of the ovary into the muscles of spayed female, or by subtotal ovariectomy. In rats with pre-tumor changes there was a rise in the gonadotropic activity of the hypophysis, while animals with developed tumors presented a reduction of hypophyseal activity. Induced tumors were successfully transplanted to spayed females with retention of estrogenic activity following transplantation.

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Authors and Affiliations

  1. Laboratory of Experimental Hornone Therapy, Institute of Experimental and Clinical Oncology, AMN SSSR, Moscow

    E. A. Ird

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  1. E. A. Ird
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Ird, E.A. Experimental ovarian tumors in rats. Bull Exp Biol Med 57, 337–339 (1964). https://doi.org/10.1007/BF00781922

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  • DOI: https://doi.org/10.1007/BF00781922

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